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Heterogeneity in EGF-binding affinities arises from negative cooperativity in an aggregating system
Scatchard analysis of the binding of EGF to its receptor yields concave up plots that indicate the presence of two classes of binding sites. However, how two independent classes of sites arise from the expression of a single EGF receptor protein has never been adequately explained. Using a new analy...
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| Main Authors: | , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2224169/ https://ncbi.nlm.nih.gov/pubmed/18165319 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707080105 |
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