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Structure-based design of an RNA-binding zinc finger

A structure-based approach was used to design RNA-binding zinc fingers that recognize the HIV-1 Rev response element (RRE). An arginine-rich α-helix from HIV-1 Rev was engineered into the zinc finger framework, and the designed fingers were shown to bind specifically to the RRE with high affinity an...

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Detalhes bibliográficos
Main Authors: McColl, Damian J., Honchell, Cynthia D., Frankel, Alan D.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC22241/
https://ncbi.nlm.nih.gov/pubmed/10449725
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