LmrR Is a Transcriptional Repressor of Expression of the Multidrug ABC Transporter LmrCD in Lactococcus lactis

LmrCD is an ABC-type multidrug transporter in Lactococcus lactis. LmrR encodes a putative transcriptional regulator. In a ΔlmrR strain, lmrCD is up-regulated. LmrR binds the promoter region of lmrCD and interacts with drugs that cause lmrCD up-regulation. This suggests that LmrR is a drug-dependent...

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Bibliographic Details
Main Authors: Agustiandari, Herfita, Lubelski, Jacek, van den Berg van Saparoea, H. Bart, Kuipers, Oscar P., Driessen, Arnold J. M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
Subjects:
Gene Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2223683/
https://ncbi.nlm.nih.gov/pubmed/17993533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.01151-07
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