c-Jun NH(2)-Terminal Kinase 2 Inhibits Gamma Interferon Production during Anaplasma phagocytophilum Infection

Gamma interferon (IFN-γ) plays a critical role in the early eradication of Anaplasma phagocytophilum. However, the mechanisms that regulate IFN-γ production upon infection remain poorly understood. Here we show that c-Jun NH(2)-terminal kinase 2 (JNK2) inhibits IFN-γ production during A. phagocytoph...

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Main Authors: Pedra, Joao H. F., Mattner, Jochen, Tao, Jian, Kerfoot, Steven M., Davis, Roger J., Flavell, Richard A., Askenase, Philip W., Yin, Zhinan, Fikrig, Erol
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2008
Teme:
Host Response and Inflammation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2223674/
https://ncbi.nlm.nih.gov/pubmed/17998313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00599-07
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