Oral Vaccination with Salmonella enterica as a Cruzipain-DNA Delivery System Confers Protective Immunity against Trypanosoma cruzi

To stimulate both local and systemic immune responses against Trypanosoma cruzi, Salmonella enterica serovar Typhimurium aroA was exploited as a DNA delivery system for cruzipain (SCz). In a murine model we compared SCz alone (GI) or coadministered with Salmonella carrying a plasmid encoding granulo...

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Autores principales: Cazorla, Silvia I., Becker, Pablo D., Frank, Fernanda M., Ebensen, Thomas, Sartori, María J., Corral, Ricardo S., Malchiodi, Emilio L., Guzmán, Carlos A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2008
Materias:
Fungal and Parasitic Infections
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2223668/
https://ncbi.nlm.nih.gov/pubmed/17967857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01163-07
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