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Disruption of the Fbxw8 Gene Results in Pre- and Postnatal Growth Retardation in Mice

CUL7 binds to SKP1, RBX1, and FBXW8 to form a cullin-RING ligase, or an SKP1-cullin-F box protein complex. The targeted disruption of the Cul7 gene in mice results in significant reduction in embryo size and neonatal lethality. In humans, CUL7 was found to be mutated in the 3-M dwarfism syndrome cha...

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Bibliografiske detaljer
Main Authors: Tsutsumi, Takeya, Kuwabara, Hiroshi, Arai, Takehiro, Xiao, Yonghong, DeCaprio, James A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2223430/
https://ncbi.nlm.nih.gov/pubmed/17998335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01665-07
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