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Disruption of the Fbxw8 Gene Results in Pre- and Postnatal Growth Retardation in Mice
CUL7 binds to SKP1, RBX1, and FBXW8 to form a cullin-RING ligase, or an SKP1-cullin-F box protein complex. The targeted disruption of the Cul7 gene in mice results in significant reduction in embryo size and neonatal lethality. In humans, CUL7 was found to be mutated in the 3-M dwarfism syndrome cha...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Microbiology (ASM)
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2223430/ https://ncbi.nlm.nih.gov/pubmed/17998335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01665-07 |
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