Thalidomide Induces Limb Anomalies by PTEN Stabilization, Akt Suppression, and Stimulation of Caspase-Dependent Cell Death

Thalidomide, a drug used for the treatment of multiple myeloma and inflammatory diseases, is also a teratogen that causes birth defects, such as limb truncations and microphthalmia, in humans. Thalidomide-induced limb truncations result from increased cell death during embryonic limb development and...

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Main Authors: Knobloch, Jürgen, Schmitz, Ingo, Götz, Katrin, Schulze-Osthoff, Klaus, Rüther, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2223408/
https://ncbi.nlm.nih.gov/pubmed/18178729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00553-07
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