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Inactivation of the Polycomb Group Protein Ring1B Unveils an Antiproliferative Role in Hematopoietic Cell Expansion and Cooperation with Tumorigenesis Associated with Ink4a Deletion

Polycomb group (PcG) proteins act as positive regulators of cell proliferation. Ring1B is a PcG gene essential for embryonic development, but its contribution to cell turnover in regenerating tissues in not known. Here, we have generated a conditional mouse mutant line to study the Ring1B role in ad...

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Bibliografski detalji
Glavni autori: Calés, Carmela, Román-Trufero, Mónica, Pavón, Leticia, Serrano, Iván, Melgar, Teresa, Endoh, Mitsuhiro, Pérez, Claudia, Koseki, Haruhiko, Vidal, Miguel
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2008
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2223390/
https://ncbi.nlm.nih.gov/pubmed/18039844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01136-07
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