Drosophila UTX Is a Histone H3 Lys27 Demethylase That Colocalizes with the Elongating Form of RNA Polymerase II

Histone H3 methylation at Lys27 (H3K27 methylation) is a hallmark of silent chromatin, while H3K4 methylation is associated with active chromatin regions. Here we report that a Drosophila JmjC family member, dUTX, specifically demethylates di- and trimethylated but not monomethylated H3K27. dUTX loc...

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Main Authors: Smith, Edwin R., Lee, Min Gyu, Winter, Benjamin, Droz, Nathan M., Eissenberg, Joel C., Shiekhattar, Ramin, Shilatifard, Ali
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2223382/
https://ncbi.nlm.nih.gov/pubmed/18039863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01504-07
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