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Simultaneous Binding of Basic Peptides at Intracellular Sites on a Large Conductance Ca(2+)-activated K(+) Channel : Equilibrium and Kinetic Basis of Negatively Coupled Ligand Interactions
The homologous Kunitz inhibitor proteins, bovine pancreatic trypsin inhibitor (BPTI) and dendrotoxin I (DTX-I), interact with large conductance Ca(2+)-activated K(+) channels (maxi-K(Ca)) by binding to an intracellular site outside of the pore to produce discrete substate events. In contrast, certai...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2223364/ https://ncbi.nlm.nih.gov/pubmed/9925826 |
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