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The β Subunit Increases the Ca(2+) Sensitivity of Large Conductance Ca(2+)-activated Potassium Channels by Retaining the Gating in the Bursting States

Coexpression of the β subunit (K(V),(Ca)β) with the α subunit of mammalian large conductance Ca(2+)- activated K(+) (BK) channels greatly increases the apparent Ca(2+) sensitivity of the channel. Using single-channel analysis to investigate the mechanism for this increase, we found that the β subuni...

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Detalhes bibliográficos
Main Authors: Nimigean, Crina M., Magleby, Karl L.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2222905/
https://ncbi.nlm.nih.gov/pubmed/10051518
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