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The effects of cosolutes on protein dynamics: The reversal of denaturant-induced protein fluctuations by trimethylamine N-oxide

The protein stabilizing effects of the small molecule osmolyte, trimethylamine N-oxide, against chemical denaturant was investigated by NMR spin-relaxation measurements and model-free analysis. In the presence of 0.7 M guanidine hydrochloride increased picosecond-nanosecond dynamics are observed in...

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Autors principals: Doan-Nguyen, Vicky, Loria, J. Patrick
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2007
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2222840/
https://ncbi.nlm.nih.gov/pubmed/17123958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.062393707
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