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Ion Channel Selectivity through Stepwise Changes in Binding Affinity
Voltage-gated Ca(2+) channels select Ca(2+) over competing, more abundant ions by means of a high affinity binding site in the pore. The maximum off rate from this site is ∼1,000× slower than observed Ca(2+) current. Various theories that explain how high Ca(2+) current can pass through such a stick...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The Rockefeller University Press
1998
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2222772/ https://ncbi.nlm.nih.gov/pubmed/9450938 |
| Oznake: |
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