Structure of the MecI repressor from Staphylococcus aureus in complex with the cognate DNA operator of mec

The dimeric repressor MecI regulates the mecA gene that encodes the penicillin-binding protein PBP-2a in methicillin-resistant Staphylococcus aureus (MRSA). MecI is similar to BlaI, the repressor for the blaZ gene of β-lactamase. MecI and BlaI can bind to both operator DNA sequences. The crystal str...

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Bibliografiske detaljer
Main Authors: Safo, Martin K., Ko, Tzu-Ping, Musayev, Faik N., Zhao, Qixun, Wang, Andrew H.-J., Archer, Gordon L.
Format: Artigo
Sprog:Inglês
Udgivet: International Union of Crystallography 2006
Fag:
Protein Structure Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2222568/
https://ncbi.nlm.nih.gov/pubmed/16582476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309106009742
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