Direct inhibition of CDK9 blocks HIV-1 replication without preventing T cell activation in primary human peripheral blood lymphocytes

HIV-1 transcription is essential for the virus replication cycle. HIV-1 Tat is a viral transactivator that strongly stimulates the processivity of RNA polymerase II (RNAPII) via recruitment of the cyclin T1/CDK9 positive transcription elongation factor, which phosphorylates the C-terminal domain (CT...

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Hlavní autoři: Salerno, Dominic, Hasham, Muneer G., Marshall, Renée, Garriga, Judit, Tsygankov, Alexander Y., Graña, Xavier
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2222555/
https://ncbi.nlm.nih.gov/pubmed/17949927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gene.2007.09.010
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