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Type-3 Ryanodine Receptors Mediate Hypoxia-, but Not Neurotransmitter-induced Calcium Release and Contraction in Pulmonary Artery Smooth Muscle Cells

In this study we examined the expression of RyR subtypes and the role of RyRs in neurotransmitter- and hypoxia-induced Ca(2+) release and contraction in pulmonary artery smooth muscle cells (PASMCs). Under perforated patch clamp conditions, maximal activation of RyRs with caffeine or inositol tripho...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zheng, Yun-Min, Wang, Qing-Song, Rathore, Rakesh, Zhang, Wan-Hui, Mazurkiewicz, Joseph E., Sorrentino, Vincenzo, Singer, Harold A., Kotlikoff, Michael I., Wang, Yong-Xiao
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2005
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2217508/
https://ncbi.nlm.nih.gov/pubmed/15795312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200409232
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