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Pore Structure Influences Gating Properties of the T-type Ca(2+) Channel α(1G)

The selectivity filter of all known T-type Ca(2+) channels is built by an arrangement of two glutamate and two aspartate residues, each one located in the P-loops of domains I–IV of the α(1) subunit (EEDD locus). The mutations of the aspartate residues to glutamate induce changes in the conduction p...

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Bibliographic Details
Main Authors: Talavera, Karel, Janssens, Annelies, Klugbauer, Norbert, Droogmans, Guy, Nilius, Bernd
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2003
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2217349/
https://ncbi.nlm.nih.gov/pubmed/12743166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200308794
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