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Involvement of Helices at the Dimer Interface in ClC-1 Common Gating

ClC-1 is a dimeric, double-pored chloride channel that is present in skeletal muscle. Mutations of this channel can result in the condition myotonia, a muscle disorder involving increased muscle stiffness. It has been shown that the dominant form of myotonia often results from mutations that affect...

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Detalhes bibliográficos
Main Authors: Duffield, Michael, Rychkov, Grigori, Bretag, Allan, Roberts, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2217322/
https://ncbi.nlm.nih.gov/pubmed/12566541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.20028741
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