Zinc inhibits human ClC-1 muscle chloride channel by interacting with its common gating mechanism

Transition metals block the muscle Cl(−) channel ClC-1, which belongs to a large family of double-barreled Cl(−) channels and transporters. In the Torpedo Cl(−) channel ClC-0, Zn(2)(+) block is closely related to the common gating mechanism that opens and closes both pores of the channel simultaneou...

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Bibliographic Details
Main Authors: Duffield, Michael D, Rychkov, Grigori Y, Bretag, Allan H, Roberts, Michael L
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2005
Subjects:
Molecular and Genomic Physiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1474776/
https://ncbi.nlm.nih.gov/pubmed/16002443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2005.091777
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