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Adenosine Triphosphate–dependent Asymmetry of Anion Permeation in the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel

The cystic fibrosis transmembrane conductance regulator (CFTR) forms a tightly regulated channel that mediates the passive diffusion of Cl(−) ions. Here we show, using macroscopic current recording from excised membrane patches, that CFTR also shows significant, but highly asymmetrical, permeability...

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Main Authors: Linsdell, Paul, Hanrahan, John W.
格式: Artigo
語言:Inglês
出版: The Rockefeller University Press 1998
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2217125/
https://ncbi.nlm.nih.gov/pubmed/9524141
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