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Mutation in the M1 Domain of the Acetylcholine Receptor α Subunit Decreases the Rate of Agonist Dissociation

We describe the kinetic consequences of the mutation N217K in the M1 domain of the acetylcholine receptor (AChR) α subunit that causes a slow channel congenital myasthenic syndrome (SCCMS). We previously showed that receptors containing αN217K expressed in 293 HEK cells open in prolonged activation...

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Bibliografiske detaljer
Main Authors: Wang, Hai-Long, Auerbach, Anthony, Bren, Nina, Ohno, Kinji, Engel, Andrew G., Sine, Steven M.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 1997
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2217038/
https://ncbi.nlm.nih.gov/pubmed/9222901
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