Constitutive activation of SHP2 in mice cooperates with ICSBP deficiency to accelerate progression to acute myeloid leukemia

Myeloproliferative disorders (MPDs) are characterized by cytokine hypersensitivity and apoptosis resistance. Development of a block in myeloid differentiation is associated with progression of MPD to acute myeloid leukemia (AML) and portends poor prognosis. Identifying molecular markers of this tran...

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Hauptverfasser: Konieczna, Iwona, Horvath, Elizabeth, Wang, Hao, Lindsey, Stephan, Saberwal, Gurveen, Bei, Ling, Huang, Weiqi, Platanias, Leonidas, Eklund, Elizabeth A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2008
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2214847/
https://ncbi.nlm.nih.gov/pubmed/18246201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33742
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