Critical role for the mitochondrial permeability transition pore and cyclophilin D in platelet activation and thrombosis

Many of the cellular responses that occur in activated platelets resemble events that take place following activation of cell-death pathways in nucleated cells. We tested the hypothesis that formation of the mitochondrial permeability transition pore (MPTP), a key signaling event during cell death,...

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Detalhes bibliográficos
Main Authors: Jobe, Shawn M., Wilson, Katina M., Leo, Lorie, Raimondi, Alejandro, Molkentin, Jeffery D., Lentz, Steven R., Di Paola, Jorge
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Hemostasis, Thrombosis, and Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2214770/
https://ncbi.nlm.nih.gov/pubmed/17989312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-05-092684
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