Dasatinib, a small-molecule protein tyrosine kinase inhibitor, inhibits T-cell activation and proliferation

Dasatinib is an oral small molecule inhibitor of Abl and Src family tyrosine kinases (SFK), including p56(Lck) (Lck). Given the central importance of Lck in transmitting signals from the T-cell receptor (TCR) signaling complex and the potent ability of dasatinib to inhibit Lck activity, we hypothesi...

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Detalhes bibliográficos
Main Authors: Schade, Andrew E., Schieven, Gary L., Townsend, Robert, Jankowska, Anna M., Susulic, Vojkan, Zhang, Rosemary, Szpurka, Hadrian, Maciejewski, Jaroslaw P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2214733/
https://ncbi.nlm.nih.gov/pubmed/17962511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-04-084814
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