Lovastatin-mediated G(1) arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase
In this paper we present the finding that lovastatin arrests cells by inhibiting the proteasome, which results in the accumulation of p21 and p27, leading to G(1) arrest. Lovastatin is an inhibitor of hydroxymethyl glutaryl (HMG)-CoA reductase, the rate-limiting enzyme in cholesterol synthesis. Prev...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1999
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22141/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10393901/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.14.7797 |
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