Lovastatin-mediated G(1) arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase

In this paper we present the finding that lovastatin arrests cells by inhibiting the proteasome, which results in the accumulation of p21 and p27, leading to G(1) arrest. Lovastatin is an inhibitor of hydroxymethyl glutaryl (HMG)-CoA reductase, the rate-limiting enzyme in cholesterol synthesis. Prev...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Rao, Sharmila, Porter, Donald C., Chen, Xiaomei, Herliczek, Thaddeus, Lowe, Michael, Keyomarsi, Khandan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22141/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10393901/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.14.7797
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