Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system

Werner and Bloom syndromes are human diseases characterized by premature age-related defects including elevated cancer incidence. Using a novel Saccharomyces cerevisiae model system for aging and cancer, we show that cells lacking the RecQ helicase SGS1 (WRN and BLM homologue) undergo premature age-...

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Detalhes bibliográficos
Main Authors: Madia, Federica, Gattazzo, Cristina, Wei, Min, Fabrizio, Paola, Burhans, William C., Weinberger, Martin, Galbani, Abdoulaye, Smith, Jesse R., Nguyen, Christopher, Huey, Selina, Comai, Lucio, Longo, Valter D.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2008
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Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213615/
https://ncbi.nlm.nih.gov/pubmed/18195102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200707154
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