A dimeric mutant of human pancreatic ribonuclease with selective cytotoxicity toward malignant cells

Monomeric human pancreatic RNase, devoid of any biological activity other than its RNA degrading ability, was engineered into a dimeric protein with a cytotoxic action on mouse and human tumor cells, but lacking any appreciable toxicity on mouse and human normal cells. This dimeric variant of human...

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Bibliographic Details

Published in:	Proc Natl Acad Sci U S A
Main Authors:	Piccoli, Renata, Di Gaetano, Sonia, De Lorenzo, Claudia, Grauso, Michela, Monaco, Carmen, Spalletti-Cernia, Daniela, Laccetti, Paolo, Cinátl, Jaroslav, Matoušek, Josef, D’Alessio, Giuseppe
Format:	Artigo
Language:	Inglês
Published:	National Academy of Sciences 1999
Subjects:	Biological Sciences
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22136/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10393896/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.14.7768
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