A dimeric mutant of human pancreatic ribonuclease with selective cytotoxicity toward malignant cells

Monomeric human pancreatic RNase, devoid of any biological activity other than its RNA degrading ability, was engineered into a dimeric protein with a cytotoxic action on mouse and human tumor cells, but lacking any appreciable toxicity on mouse and human normal cells. This dimeric variant of human...

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Detalhes bibliográficos
Main Authors: Piccoli, Renata, Di Gaetano, Sonia, De Lorenzo, Claudia, Grauso, Michela, Monaco, Carmen, Spalletti-Cernia, Daniela, Laccetti, Paolo, Cinátl, Jaroslav, Matoušek, Josef, D’Alessio, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC22136/
https://ncbi.nlm.nih.gov/pubmed/10393896
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