Blocking TNF-α in mice reduces colorectal carcinogenesis associated with chronic colitis

The inflammatory bowel disease ulcerative colitis (UC) frequently progresses to colon cancer. To understand the mechanisms by which UC patients develop colon carcinomas, we used a mouse model of the disease whereby administration of azoxymethane (AOM) followed by repeated dextran sulfate sodium (DSS...

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Autores principales: Popivanova, Boryana K., Kitamura, Kazuya, Wu, Yu, Kondo, Toshikazu, Kagaya, Takashi, Kaneko, Shiuchi, Oshima, Masanobu, Fujii, Chifumi, Mukaida, Naofumi
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2008
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213370/
https://ncbi.nlm.nih.gov/pubmed/18219394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32453
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