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Combining Efficient Conformational Sampling with a Deformable Elastic Network Model Facilitates Structure Refinement at Low Resolution
Structural studies of large proteins and protein assemblies are a difficult and pressing challenge in molecular biology. Experiments often yield only low-resolution or sparse data which are not sufficient to fully determine atomistic structures. We have developed a general geometry-based algorithm t...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2213367/ https://ncbi.nlm.nih.gov/pubmed/18073112 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2007.09.021 |
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