A Human Severe Combined Immunodeficiency (SCID) Condition with Increased Sensitivity to Ionizing Radiations and Impaired V(D)J Rearrangements Defines a New DNA Recombination/Repair Deficiency

The products of recombination activating gene (RAG)1 and RAG2 initiate the lymphoid-specific phase of the V(D)J recombination by creating a DNA double-strand break (dsb), leaving hairpin-sealed coding ends. The next step uses the general DNA repair machinery of the cells to resolve this dsb. Several...

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Main Authors: Nicolas, Nathalie, Moshous, Despina, Cavazzana-Calvo, Marina, Papadopoulo, Dora, de Chasseval, Régina, Le Deist, Françoise, Fischer, Alain, de Villartay, Jean-Pierre
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Rockefeller University Press 1998
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Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213354/
https://ncbi.nlm.nih.gov/pubmed/9705945
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