Partial T and B lymphocyte immunodeficiency and predisposition to lymphoma in patients with hypomorphic mutations in Artemis

We have previously described the identification of Artemis, a factor involved in the nonhomologous end joining (NHEJ) phase of V(D)J recombination of T and B cell receptor genes. Null mutations of the Artemis gene result in a complete absence of T and B lymphocytes that is associated with increased...

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Detalhes bibliográficos
Main Authors: Moshous, Despina, Pannetier, Christophe, Chasseval, Régina de, Deist, Françoise le, Cavazzana-Calvo, Marina, Romana, Serge, Macintyre, Elizabeth, Canioni, Danielle, Brousse, Nicole, Fischer, Alain, Casanova, Jean-Laurent, Villartay, Jean-Pierre de
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC151863/
https://ncbi.nlm.nih.gov/pubmed/12569164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200316774
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