DC-STAMP is essential for cell–cell fusion in osteoclasts and foreign body giant cells

Osteoclasts are bone-resorbing cells that play a pivotal role in bone remodeling. Osteoclasts form large multinuclear giant cells by fusion of mononuclear osteoclasts. How cell fusion is mediated, however, is unclear. We identify the dendritic cell–specific transmembrane protein (DC-STAMP), a putati...

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Bibliographic Details
Main Authors: Yagi, Mitsuru, Miyamoto, Takeshi, Sawatani, Yumi, Iwamoto, Katsuya, Hosogane, Naobumi, Fujita, Nobuyuki, Morita, Kozo, Ninomiya, Ken, Suzuki, Toru, Miyamoto, Kana, Oike, Yuichi, Takeya, Motohiro, Toyama, Yoshiaki, Suda, Toshio
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2005
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Brief Definitive Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213087/
https://ncbi.nlm.nih.gov/pubmed/16061724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20050645
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