Calcium-sensing soluble adenylyl cyclase mediates TNF signal transduction in human neutrophils

Through chemical screening, we identified a pyrazolone that reversibly blocked the activation of phagocyte oxidase (phox) in human neutrophils in response to tumor necrosis factor (TNF) or formylated peptide. The pyrazolone spared activation of phox by phorbol ester or bacteria, bacterial killing, T...

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Bibliografiske detaljer
Main Authors: Han, Hyunsil, Stessin, Alexander, Roberts, Julia, Hess, Kenneth, Gautam, Narinder, Kamenetsky, Margarita, Lou, Olivia, Hyde, Edward, Nathan, Noah, Muller, William A., Buck, Jochen, Levin, Lonny R., Nathan, Carl
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2005
Fag:
Brief Definitive Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213086/
https://ncbi.nlm.nih.gov/pubmed/16043520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20050778
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