Calcium-sensing soluble adenylyl cyclase mediates TNF signal transduction in human neutrophils

Through chemical screening, we identified a pyrazolone that reversibly blocked the activation of phagocyte oxidase (phox) in human neutrophils in response to tumor necrosis factor (TNF) or formylated peptide. The pyrazolone spared activation of phox by phorbol ester or bacteria, bacterial killing, T...

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Detalhes bibliográficos
Principais autores: Han, Hyunsil, Stessin, Alexander, Roberts, Julia, Hess, Kenneth, Gautam, Narinder, Kamenetsky, Margarita, Lou, Olivia, Hyde, Edward, Nathan, Noah, Muller, William A., Buck, Jochen, Levin, Lonny R., Nathan, Carl
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2005
Assuntos:
Brief Definitive Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213086/
https://ncbi.nlm.nih.gov/pubmed/16043520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20050778
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