Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling

Endotoxin, a bacterial lipopolysaccharide (LPS), causes fatal septic shock via Toll-like receptor (TLR)4 on effector cells of innate immunity like macrophages, where it activates nuclear factor κB (NF-κB) and mitogen-activated protein (MAP) kinases to induce proinflammatory cytokines such as tumor n...

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Bibliographic Details
Main Authors: Shinohara, Hisaaki, Inoue, Akane, Toyama-Sorimachi, Noriko, Nagai, Yoshinori, Yasuda, Tomoharu, Suzuki, Hiromi, Horai, Reiko, Iwakura, Yoichiro, Yamamoto, Tadashi, Karasuyama, Hajime, Miyake, Kensuke, Yamanashi, Yuji
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2005
Subjects:
Brief Definitive Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213020/
https://ncbi.nlm.nih.gov/pubmed/15699069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20041817
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