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Independent roles for IL-2 and GATA-3 in stimulating naive CD4(+) T cells to generate a Th2-inducing cytokine environment

T cell receptor (TCR) signaling plays an important role in early interleukin (IL)-4 production by naive CD4(+) T cells. This “antigen-stimulated” early IL-4 is sufficient for in vitro Th2 differentiation. Here, we provide evidence that early IL-4 production by naive CD4(+) T cells stimulated with co...

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Autors principals: Yamane, Hidehiro, Zhu, Jinfang, Paul, William E.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212937/
https://ncbi.nlm.nih.gov/pubmed/16172258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20051304
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