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CD152 (CTLA-4) Determines the Unequal Resistance of Th1 and Th2 Cells against Activation-induced Cell Death by a Mechanism Requiring PI3 Kinase Function

Survival of antigen-experienced T cells is essential for the generation of adaptive immune responses. Here, we show that the genetic and antibody-mediated inactivation of CD152 (cytotoxic T lymphocyte antigen 4) in T helper (Th) effector cells reduced the frequency of nonapoptotic cells in a complet...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Pandiyan, Pushpa, Gärtner, Dagmar, Soezeri, Osman, Radbruch, Andreas, Schulze-Osthoff, Klaus, Brunner-Weinzierl, Monika C.
פורמט: Artigo
שפה:Inglês
יצא לאור: The Rockefeller University Press 2004
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212725/
https://ncbi.nlm.nih.gov/pubmed/15007096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20031058
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