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Activation of erythropoietin receptor in the absence of hormone by a peptide that binds to a domain different from the hormone binding site

Applying a homology search method previously described, we identified a sequence in the extracellular dimerization site of the erythropoietin receptor, distant from the hormone binding site. A peptide identical to that sequence was synthesized. Remarkably, it activated receptor signaling in the abse...

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Библиографические подробности
Главные авторы: Naranda, Tatjana, Wong, Kenneth, Kaufman, R. Ilene, Goldstein, Avram, Olsson, Lennart
Формат: Artigo
Язык:Inglês
Опубликовано: The National Academy of Sciences 1999
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC22127/
https://ncbi.nlm.nih.gov/pubmed/10377456
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