Loss of spermatogonia and wide-spread DNA methylation defects in newborn male mice deficient in DNMT3L

BACKGROUND: Formation of haploid spermatozoa capable of fertilization requires proper programming of epigenetic information. Exactly how DNMT3L (DNA methyltransferase 3-Like), a postulated regulator of DNA methyltransferase activity, contributes to DNA methylation pattern acquisition during gametoge...

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Bibliographic Details
Main Authors: La Salle, Sophie, Oakes, Christopher C, Neaga, Oana R, Bourc'his, Déborah, Bestor, Timothy H, Trasler, Jacquetta M
Format: Artigo
Language:Inglês
Published: BioMed Central 2007
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212652/
https://ncbi.nlm.nih.gov/pubmed/17875220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-213X-7-104
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