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Receptor Editing Occurs Frequently during Normal B Cell Development

Allelic exclusion is established in development through a feedback mechanism in which the assembled immunoglobulin (Ig) suppresses further V(D)J rearrangement. But Ig expression sometimes fails to prevent further rearrangement. In autoantibody transgenic mice, reactivity of immature B cells with aut...

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Detalhes bibliográficos
Main Authors: Retter, Marc W., Nemazee, David
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 1998
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212498/
https://ncbi.nlm.nih.gov/pubmed/9763602
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