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Interleukin 6 Influences Germinal Center Development and Antibody Production via a Contribution of C3 Complement Component

Mice rendered deficient for interleukin (IL) 6 by gene targeting were evaluated for their response to T cell–dependent antigens. Antigen-specific immunoglobulin (Ig)M levels were unaffected whereas all IgG isotypes showed varying degrees of alteration. Germinal center reactions occurred but remained...

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Autors principals: Kopf, Manfred, Herren, Suzanne, Wiles, Michael V., Pepys, Mark B., Kosco-Vilbois, Marie H.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 1998
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212418/
https://ncbi.nlm.nih.gov/pubmed/9815267
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