Загрузка...

Alteration of a Single Hydrogen Bond between Class II Molecules and Peptide Results in Rapid Degradation of Class II Molecules after Invariant Chain Removal

To characterize the importance of a highly conserved region of the class II β chain, we introduced an amino acid substitution that is predicted to eliminate a hydrogen bond formed between the class II molecule and peptide. We expressed the mutated β chain with a wild-type α chain in a murine L cell...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Ceman, Stephanie, Wu, Shenhong, Jardetzky, Theodore S., Sant, Andrea J.
Формат: Artigo
Язык:Inglês
Опубликовано: The Rockefeller University Press 1998
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212374/
https://ncbi.nlm.nih.gov/pubmed/9841927
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!