Mice lacking complex gangliosides develop Wallerian degeneration and myelination defects

Gangliosides are a family of sialic acid-containing glycosphingolipids highly enriched in the mammalian nervous system. Although they are the major sialoglycoconjugates in the brain, their neurobiological functions remain poorly defined. By disrupting the gene for a key enzyme in complex ganglioside...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Sheikh, Kazim A., Sun, Ji, Liu, Yujing, Kawai, Hiromichi, Crawford, Thomas O., Proia, Richard L., Griffin, John W., Schnaar, Ronald L.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1999
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22120/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10377449/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.13.7532
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