Deletion of the Nucleotide Excision Repair Gene Ercc1 Reduces Immunoglobulin Class Switching and Alters Mutations Near Switch Recombination Junctions

The structure-specific endonuclease ERCC1-XPF is an essential component of the nucleotide excision DNA repair pathway. ERCC1-XPF nicks double-stranded DNA immediately adjacent to 3′ single-strand regions. Substrates include DNA bubbles and flaps. Furthermore, ERCC1 interacts with Msh2, a mismatch re...

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Main Authors: Schrader, Carol E., Vardo, Joycelyn, Linehan, Erin, Twarog, Michael Z., Niedernhofer, Laura J., Hoeijmakers, Jan H.J., Stavnezer, Janet
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2004
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2211985/
https://ncbi.nlm.nih.gov/pubmed/15280420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20040052
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