Statins Inhibit HIV-1 Infection by Down-regulating Rho Activity

Human immunodeficiency virus (HIV)-1 infectivity requires actin-dependent clustering of host lipid raft–associated receptors, a process that might be linked to Rho guanosine triphosphatase (GTPase) activation. Rho GTPase activity can be negatively regulated by statins, a family of drugs used to trea...

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Detalhes bibliográficos
Main Authors: del Real, Gustavo, Jiménez-Baranda, Sonia, Mira, Emilia, Lacalle, Rosa Ana, Lucas, Pilar, Gómez-Moutón, Concepción, Alegret, Marta, Peña, Jose María, Rodríguez-Zapata, Manuel, Alvarez-Mon, Melchor, Martínez-A., Carlos, Mañes, Santos
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2004
Assuntos:
Brief Definitive Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2211926/
https://ncbi.nlm.nih.gov/pubmed/15314078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20040061
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