Gene Dosage–limiting Role of Aire in Thymic Expression, Clonal Deletion, and Organ-specific Autoimmunity

Inactivation of the autoimmune regulator (Aire) gene causes a rare recessive disorder, autoimmune polyendocrine syndrome 1 (APS1), but it is not known if Aire-dependent tolerance mechanisms are susceptible to the quantitative genetic changes thought to underlie more common autoimmune diseases. In mi...

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Detalhes bibliográficos
Main Authors: Liston, Adrian, Gray, Daniel H.D., Lesage, Sylvie, Fletcher, Anne L., Wilson, Judith, Webster, Kylie E., Scott, Hamish S., Boyd, Richard L., Peltonen, Leena, Goodnow, Christopher C.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2211852/
https://ncbi.nlm.nih.gov/pubmed/15492124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20040581
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