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Short-lived protease–serpin complexes: Partial disruption of the rat trypsin active site
Serpins inhibit serine proteases by mechanically disrupting the protease active site. The protease first reacts with the serpin's reactive center loop (RCL) to form an acylenzyme. Then the RCL inserts into a β-sheet in the body of the serpin, translocating the attached protease ∼70 Å and deform...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Cold Spring Harbor Laboratory Press
2007
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2211700/ https://ncbi.nlm.nih.gov/pubmed/17962402 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.073111207 |
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