Viroporin potential of the lentivirus lytic peptide (LLP) domains of the HIV-1 gp41 protein

BACKGROUND: Mechanisms by which HIV-1 mediates reductions in CD4+ cell levels in infected persons are being intensely investigated, and have broad implications for AIDS drug and vaccine development. Virally induced changes in membrane ionic permeability induced by lytic viruses of many families cont...

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Bibliographic Details
Main Authors: Costin, Joshua M, Rausch, Joshua M, Garry, Robert F, Wimley, William C
Format: Artigo
Language:Inglês
Published: BioMed Central 2007
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2211469/
https://ncbi.nlm.nih.gov/pubmed/18028545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-4-123
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