Cancer-specific chromosome alterations in the constitutive fragile region FRA3B

We have sequenced 870 kilobases of the FHIT/FRA3B locus, from FHIT intron 3 to intron 7. The locus is AT rich (61.5%) and Alu poor (6.2%), and it apparently does not harbor other genes. In a detailed analysis of the 308-kilobase region between FHIT exon 5 and the telomeric end of intron 3, a region...

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Autores principales: Mimori, Koshi, Druck, Teresa, Inoue, Hiroshi, Alder, Hansjuerg, Berk, Lori, Mori, Masaki, Huebner, Kay, Croce, Carlo M.
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 1999
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC22107/
https://ncbi.nlm.nih.gov/pubmed/10377436
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